How Does Qwo Eliminate Cellulite?

Qwo is an FDA-approved cellulite injection treatment for adult women. There are no buts about it; cellulite sucks. Cellulite affects more than 90% of women to some degree. [1] Qwo offers a solution for these bothersome dimples that diet and exercise cannot combat. [2] This popular treatment option provides highly noticeable results without the need for invasive measures. 

Sound like something you’d be interested in? Dr. Friedlander is more than happy to discuss cellulite treatment options with you during a consultation. You can fill out our online form or call our Roseville, CA location at (916) 347-7755. We are also please to offer virtual consultations to accommodate your busy schedule. 


Qwo is an injectable treatment that is administered into the individual cellulite dimples. Qwo works by breaking down the connection of fibrous tissue with an injection of collagen disturbing enzymes. [1] This disturbance allows for the release of the tethering bands of tissue. In turn, fat cells can reposition so the skin above can smooth out, no longer creating dimples. Additionally, these enzymes help to rebuild collagen, an important substance for skin elasticity. Qwo allows you to be confident in your smooth skin

What Causes Cellulite?

While fat plays a role in the visibility of cellulite, the main cause is connective fibrous tissue bands called fibrous septae. These connective fibers bind the skin to muscles; fat exists in between. The fibers do not stretch, so when fat cells grow, the skin above stays in place creating the dimpling effect we know as cellulite. [1] 

There does not need to be a lot of fat for this effect to take place, adding to why so many women are burdened by this annoying imperfection. A large amount of fat will contribute to the appearance of cellulite though since it stretches the surrounding skin further than the tethered skin can reach. Additionally, genetics can play a role.

Qwo provides the solution to a problem you cannot fix on your own. 

Qwo Versus Other Cellulite Treatments

Qwo is not the first cellulite reduction treatment on the market, but it is the least invasive compared to older treatments like Cellfina and Cellulaze. These two latter-mentioned devices are inserted into the skin and utilize subcision to actually cut the connective fibers. The end result of all these treatments is the same, the fibers are released so cellulite dimples go away. However, Qwo is a simple injection; no incisions are necessary. [3]


Candidates for Qwo treatment are adult women who suffer from dimpling of the skin on the buttocks or thighs. Women tend to experience cellulite more than men due to the positioning of the connective fibers. Men’s connective fibers lay in a criss-cross pattern while women’s are perpendicular to the skin, hence why dimples are created. [4]

You are not a good candidate for Qwo if you are currently breastfeeding, pregnant, or have an active skin infection on the treatment site. Patients should not have any bleeding disorders or allergies to collagenase products. 

Qwo is not designed to tighten loose skin; it smooths dimples to the current skin elasticity. If you have loose skin and also wish to remove fat, Vaser Lipo may be an ideal procedure for you. You can read more on our blog

Personal Consultation

Your consultation at Norcal Liposculpture will consist of an examination of the cellulite on the buttocks or thighs and a discussion about your medical history and current medications taken. A personalized course of treatment will be drawn up based on these. If you are interested in any other body sculpting treatments, Dr. Friedlander is happy to talk about them at this time as well. 

Our goal at Norcal Liposculpture is to educate our patients on the treatments and procedures they are receiving so they come in the day of their appointment confident. We have provided Northern California patients with the body of their dreams for years and continue to strive to deliver superior results. Contact us today to schedule an in-person or virtual consultation. We are also happy to assist out-of-town patients with recommendation to make your visit as smooth and pleasant as possible. 


A week before your Qwo appointment, do not consume alcohol, nicotine, or blood thinning medications. You will provide the doctor with your current supplements and medications incase any of these need to be temporarily paused as well. It is recommended to take Arnica before treatment, if you are not allergic, to help reduce bruising. On the day of your procedure, do not shave or apply lotions or creams to the areas being treated. It is best to wear loose fitting pants or a dress for comfort. If additional preparation instructions are necessary for your personalized treatment, these will be provided to you before your appointment date. 


Since Qwo only consists of injections, numbing is not necessary. Patients will lie on their stomachs for treatment to make sure the muscles are not engaged. The best dimples to target are the ones that are well-defined; these will be marked before treatment. The needle is then injected into the fat layer where the fibrous tissue resides. The needle is not constantly removed, it is simply repositioned to release the fibrous tissue responsible for pulling on the skin. Qwo treatment takes roughly half an hour and is personally performed by Dr. Friedlander.  

Buttocks treatment will consist of 24 injections per appointment. Treatment consists of three appointments spread three weeks apart. Please inquire about treatment on the thighs during your consultation. 


Qwo does not require any downtime, but you may feel sore for a couple of days. This should not stop you from continuing your normal routine. Bruising is to be expected with collagenase clostridium histolyticum enzymes but it does dissipate on its own. Because of this, make sure you do not schedule your sessions during a time that you plan on wearing swimsuits or revealing clothing. Bruising becomes less profound with each treatment round. 


If following the recommended course of treatment, you can see results about a month after your third and final treatment. The results of Qwo are long-lasting because it addresses cellulite at the source rather than very temporary topical treatments. The fibrous tissues do not regrow so once they are disconnected from the skin, the connection is not restored. Therefore, your skin will remain beautifully smooth.*

*Results may vary 

Corresponding & Complementary Procedures 

If fat removal is something you are also interested in, Norcal Liposculpture is pleased to provide Sacramento men and women with the advanced body-sculpting procedure Vaser Lipo. Vaser Lipo (Vibration Amplification of Sound Energy at Resonance) uses sound waves to break down fat cells for easier removal. This state-of-the-art liposuction technique allows for the removal of even more fat than traditional liposuction with less damage to surrounding tissue. With Vaser, Dr. Friedlander is also able to target fat closer to the surface of the skin, allowing for the reveal of greater definition and contour. And to top it all off, this procedure provides moderate skin tightening!

If you are close to your ideal body weight and simply want more definition, we also offer Vaser Hi-Def Lipo. Vaser Hi-Def Lipo is reserved for those who are close to their body goal but a layer of fat above the muscles is simply resistant to exercise. This lipo technique reveals the contour you’ve been working so hard for. 

Dr. Friedlander is a top body sculpting surgeon, and having trained with Vaser pioneer Dr. John Millard and world-renowned surgeon Dr. Grant Hamlet, his results speak for themself. 


The cost of Qwo depends on the treatment area and how many treatments you receive. We can give you a personalized quote when you come in for a consultation at our Roseville office. Dr. Friedlander is happy to provide women of the greater Sacramento area with smooth skin and help them regain the confidence to wear what they want!


Is Qwo a surgical cellulite treatment?

No; Qwo is a non-surgical cellulite treatment. It involves simple injections into the dimples you want to smooth. 

Is there downtime after a Qwo treatment?

There is no downtime after a Qwo session. The injection process is quick and you can return to work or your daily activities. 

Can Qwo be performed on men?

Currently, Qwo is FDA-approved for cellulite treatment in adult women. [5]


  1. Kaufman-Janette JA, Bass LS, Xiang Q, McLane MP, Kirby MT, Vijayan S. Efficacy, Safety, and Durability of Response of Collagenase Clostridium Histolyticum-aaes for Treating Cellulite. Plast Reconstr Surg Glob Open. 2020;8(12):e3316. Published 2020 Dec 23. doi:10.1097/GOX.0000000000003316
  2. Friedmann DP, Vick GL, Mishra V. Cellulite: a review with a focus on subcision. Clin Cosmet Investig Dermatol. 2017;10:17-23. Published 2017 Jan 7. doi:10.2147/CCID.S95830
  3. Sadick N. Treatment for cellulite. Int J Womens Dermatol. 2018;5(1):68-72. Published 2018 Oct 22. doi:10.1016/j.ijwd.2018.09.002
  4. Bass LS, Kaminer MS. Insights Into the Pathophysiology of Cellulite: A Review. Dermatol Surg. 2020;46 Suppl 1(1):S77-S85. doi:10.1097/DSS.0000000000002388
  5. Learn About QWO® (collagenase clostridium histolyticum-aaes). Published 2021. Accessed September 26, 2022.
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